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Cancer Treatment: Commonly used for the treatment and prevention of hormone-sensitive breast cancer.
Strength 40mg: Each tablet contains 40mg Tamoxifen; suitable for higher-dose requirements.
Hormonal Therapy: Blocks estrogen receptors to slow or stop cancer cell growth.
Long-Term Use: Often prescribed for extended periods depending on the patient’s condition.
Doctor Supervised: Requires regular monitoring and medical supervision throughout the treatment.
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An effective treatment and preventative measure for estrogen receptor-positive (ER+) breast cancer is tamoxifen. People who are premenopausal or postmenopausal can use it. Developed in the 1960s, it is well-researched and accepted by regulatory agencies such as FDA in multiple indications related to cancer.
Tamoxifen acts by competitive binding to the estrogen receptors of the breast cancer cells thereby inhibiting the effect of estrogen which stimulates the growth of cancer. It can perform as estrogen in some tissues, like bones and the uterus, and provide positive hormonal action in these regions.
Indications & Uses
Adjuvant Therapy: ER+ breast cancer that occurs after surgery and/or radiation therapy to minimize the chances of recurrence – in women and men.
Metastatic Breast Cancer: When cancer spreads in ER+.
Preventive: In high-risk individuals (e.g., DCIS, family history, BRCA mutation carriers), generally 5 years of therapy, and protection appears to be ongoing .
Off‑label: Ovulation induction, mastalgia, gynecomastia, and infertility in males- at different doses.
Dosage Administration
Usual dosage: 20-40mg per day orally.
The high dose regimens (40 mg/day) can be divided into two doses per day (20mg in the morning and in the evening).
Duration: Typically 5 years in the adjuvant and preventive context; up to 10 years can have furthermore advantages, according to ATLAS and aTTom trials.
Administration: It could be administered with or without food. The dosage will depend on the recommendation of the oncologist based on the condition of the patient and other ongoing treatments.
Benefits
Prevents recurrence: When taken as prescribed, reduces the risk of cancer resurgence by a great margin.
Prevention: Reduces risk in high-risk populations by as much as 40 percent.
Bone protection: Provides some estrogenic action in bone tissue, and preserves bone density .
Safety Profile & Side Effects
Reproductive: Changes: Missed periods, vaginal discharge or bleeding (23 55 percent), vaginal dryness.
Others: Nausea, fatigue, weight changes, fluid buildup, mood swings, headache, joint aches, hair loss .
Less common effects
Eye issues: Cataracts, cornea alterations, blurred vision.
Skin reactions: Rash, dryness, itching .
Metabolic: Elevated triglycerides, liver enzyme rise, fatty liver risk
Sexual health: Loss of libido, male impotence .
Serious Risks
Thromboembolic events: Deep vein thrombosis, pulmonary embolism, increased risk of stroke; uncommon, can be life-threatening.
Endometrial/Uterine cancer: There is a slightly elevated risk, primarily in post‑menopausal women; they should be watchful of abnormal bleeding.
Eye problems: Cataract and visual disturbance .
Liver toxicity: Hepatic effects, risk of fatty liver; should be monitored through liver function test.
Serious: Chest pain, swelling of the legs, sudden changes in vision, severe headaches or difficulties walking should be medically assisted.
Drug Interactions
CYP enzyme interactions: Tamoxifen is broken down by CYP2D6; enzyme inhibiting drugs (e.g., certain SSRIs such as paroxetine, fluoxetine) may decrease tamoxifen effectiveness and possibly lead to increased risk of mortality.
Anticoagulants: May increase bleeding.
Aromatase inhibitors: Can change the way tamoxifen is broken down in the body-check with your physician.
It is important to always check with your doctor or pharmacist when taking any new medication, even OTC and herbal remedies.
Monitoring Guidelines
Watch out to the possibility of the blood clots or uterine concerns; pelvic/gynecological examinations in case of bleeding.
Eye tests advised when there are visual symptoms.
Use every day at a similar time.
Inform of pregnancy, breastfeeding or intention to become pregnant.
Balanced diet, moderate exercising and hydration can be used to overcome some of the side effects such as hot flashes and fatigue.
dangerous or chronic symptoms should be reported as soon as possible.
Certified purity: Direct sourcing, EU/ISO-manufacturing.
Favourable prices: Discounts offered in bulk.
Express delivery: Trusted delivery across the country.
Expert recommendation: Clinical pharmacists at hand to consult.
